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  • Showing results for activity of amphotericin b in lipid emulsion in the initial treatment of canine leishmaniasis. Your search for Activity of amphotericin B in lipid emulsion in the inital treatment of canine leishmaniasis retrieved no results.
J Small Anim Pract. 2001 Apr;42(4):170-5.

Activity of amphotericin B in lipid emulsion in the initial treatment of canine leishmaniasis.

Author information

1
Clinique Veterinaire, Carros, France.

Abstract

Amphotericin B was given to 19 dogs with leishmaniasis. The drug was diluted in an emulsion prepared by mixing 50 mg of amphotericin B desoxycholate with 40 ml of sterile water and 10 ml of soya bean oil solution. The dogs were infused over nearly one hour with 50 ml/kg of normal saline followed by 10 ml/kg of mannitol 20 per cent. The mixture was then loaded over 30 to 60 minutes using a syringe pump. The emulsion was given twice weekly, at an increasing dosage (from 1 to 2.5 mg/kg bodyweight), for a minimum of eight injections. All 17 dogs receiving a total dosage of more than 10 mg/kg were clinically cured by the end of the treatment, and 14 of these had a negative polymerase chain reaction test on bone marrow.

PMID:
11327663
[Indexed for MEDLINE]

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