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Muscle Nerve. 2015 Oct;52(4):640-8. doi: 10.1002/mus.24581. Epub 2015 Aug 14.

Activity attenuates skeletal muscle fiber damage after ischemia and reperfusion.

Author information

1
Extremity Trauma and Regenerative Medicine Research Program, United States Army Institute of Surgical Research, 3698 Chambers Pass, Fort Sam Houston, Texas, 78234-6315, USA.

Abstract

INTRODUCTION:

In this investigation we aimed to determine whether: (1) physical activity protects rat skeletal muscle from ischemia/reperfusion (I/R) injury; and (2) continued activity after I/R improves the rate of healing.

METHODS:

Rats were divided into sedentary or active (voluntary wheel running) groups. Active rats ran for 4 weeks before I/R or 4 weeks before plus 4 weeks after I/R.

RESULTS:

Activity before I/R resulted in 73.2% less muscle damage (Evans blue dye inclusion). Sedentary and active rats had a similar decline in neural-evoked (∼ 99%) and directly stimulated (∼ 70%) in vivo muscle torque, and a similar reduction in junctophilin 1. Active rats produced 19% and 15% greater neural-evoked torque compared with sedentary rats at 14 and 28 days postinjury, respectively, although the rate of recovery appeared similar.

CONCLUSIONS:

Activity protects against long-term muscle damage, but not short-term neural injury or excitation-contraction uncoupling. Continued activity neither accelerates nor hinders the rate of functional recovery.

KEYWORDS:

exercise; junctophilin 1; muscle injury; rats; trauma

PMID:
25641705
DOI:
10.1002/mus.24581
[Indexed for MEDLINE]

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