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Science. 1997 Aug 29;277(5330):1313-6.

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.

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1
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. Further, in old sgs1 cells the nucleolus is enlarged and fragmented-changes that also occur in old wild-type cells. These findings suggest a conserved mechanism of cellular aging that may be related to nucleolar structure.

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PMID:
9271578
[Indexed for MEDLINE]
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