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AGPAT3 Gene polymorphisms are associated with milk production traits in Chinese Holstein cows.
Sun X, Liang Y, Gao Q, Guo J, Tang C, Shi K, Yang Z, Mao Y. Sun X, et al. J Dairy Res. 2021 Aug;88(3):247-252. doi: 10.1017/S0022029921000546. Epub 2021 Jul 15. J Dairy Res. 2021. PMID: 34261571
The current study reports the identification of previously undiscovered single-nucleotide polymorphisms (SNPs) in the bovine AGPAT3 gene and further investigates their associations with milk production traits. ...The GG genotype of SNP g.28731 A > G was associated with …
The current study reports the identification of previously undiscovered single-nucleotide polymorphisms (SNPs) in the bovine AGPAT3 g …
Ferroptosis-related biomarkers for Alzheimer's disease: Identification by bioinformatic analysis in hippocampus.
Wang B, Fu C, Wei Y, Xu B, Yang R, Li C, Qiu M, Yin Y, Qin D. Wang B, et al. Front Cell Neurosci. 2022 Nov 16;16:1023947. doi: 10.3389/fncel.2022.1023947. eCollection 2022. Front Cell Neurosci. 2022. PMID: 36467613 Free PMC article.
Using STRING (https://cn.string-db.org/) and Cytoscape with CytoHubba, the top 10 genes (RB1, AGPAT3, SESN2, KLHL24, ALOX15B, CA9, GDF15, DPP4, PRDX1, UBC, FTH1, ASNS, GOT1, PGD, ATG16L1, SLC3A2, DDIT3, RPL8, VDAC2, GLS2, MTOR, HSF1, AKR1C3, NCF2) were identified as target …
Using STRING (https://cn.string-db.org/) and Cytoscape with CytoHubba, the top 10 genes (RB1, AGPAT3, SESN2, KLHL24, ALOX15B, CA9, GD …
Dietary omega-3 fatty acid does not improve male infertility caused by lysophospholipid acyltransferase 3 (LPLAT3/AGPAT3) deficiency.
Nagata K, Kakizaki Y, Yanagida K, Arai T, Nakano K, Hamano F, Goto M, Okamura T, Shimizu T, Shindou H. Nagata K, et al. Biochem Biophys Res Commun. 2023 Jun 30;663:179-185. doi: 10.1016/j.bbrc.2023.04.043. Epub 2023 Apr 23. Biochem Biophys Res Commun. 2023. PMID: 37121128 Free article.
Docosahexaenoic acid (DHA), an omega-3 fatty acid, usually presents as a constituent of phospholipids in the cellular membrane. Lysophospholipid acyltransferase 3 (LPLAT3; AGPAT3) is the primary enzyme that incorporates DHA into phospholipids. ...
Docosahexaenoic acid (DHA), an omega-3 fatty acid, usually presents as a constituent of phospholipids in the cellular membrane. Lysophosphol …
A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome.
Malik MA, Saqib MAN, Mientjes E, Acharya A, Alam MR, Wallaard I, Schrauwen I, Bamshad MJ, Santos-Cortez RLP, Elgersma Y, Leal SM, Ansar M. Malik MA, et al. Eur J Hum Genet. 2023 Dec;31(12):1447-1454. doi: 10.1038/s41431-023-01475-w. Epub 2023 Oct 11. Eur J Hum Genet. 2023. PMID: 37821758
Using genome wide genotyping and exome sequencing, we identified a nonsense variant c.747 C > A (p.Tyr249Ter) in exon 7 of AGPAT3 which co-segregates with the disease phenotype. Western blot analysis of overexpressed WT and mutant AGPAT3 in HEK293T cells showed t …
Using genome wide genotyping and exome sequencing, we identified a nonsense variant c.747 C > A (p.Tyr249Ter) in exon 7 of AGPAT3 …
Membrane topology of human AGPAT3 (LPAAT3).
Schmidt JA, Yvone GM, Brown WJ. Schmidt JA, et al. Biochem Biophys Res Commun. 2010 Jul 9;397(4):661-7. doi: 10.1016/j.bbrc.2010.05.149. Epub 2010 Jun 9. Biochem Biophys Res Commun. 2010. PMID: 20537980 Free PMC article.
Recently, a new function for AGPATs was discovered when it was determined that human AGPAT3/LPAAT3 is involved in the structure and function of the Golgi complex. Here we have determined the topological orientation of human AGPAT3/LPAAT3. AGPAT3/LPAAT3 posses …
Recently, a new function for AGPATs was discovered when it was determined that human AGPAT3/LPAAT3 is involved in the structure and f …
A post-GWAS confirming the genetic effects and functional polymorphisms of AGPAT3 gene on milk fatty acids in dairy cattle.
Shi L, Wu X, Yang Y, Ma Z, Lv X, Liu L, Li Y, Zhao F, Han B, Sun D. Shi L, et al. J Anim Sci Biotechnol. 2021 Feb 1;12(1):24. doi: 10.1186/s40104-020-00540-4. J Anim Sci Biotechnol. 2021. PMID: 33522959 Free PMC article.
Among them, two SNPs, ARS-BFGL-NGS-109493 and BTA-56389-no-rs associated with C18index (P = 0.0459), were located in the upstream of 1-acylglycerol-3-phosphate O-acyltransferase 3 (AGPAT3) gene. AGPAT3 is involved in glycerol-lipid, glycerol-phospholipid metabolism …
Among them, two SNPs, ARS-BFGL-NGS-109493 and BTA-56389-no-rs associated with C18index (P = 0.0459), were located in the upstream of 1-acylg …
Exogenous H2 S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W. Zhang S, et al. J Cachexia Sarcopenia Muscle. 2023 Dec;14(6):2719-2732. doi: 10.1002/jcsm.13347. Epub 2023 Oct 30. J Cachexia Sarcopenia Muscle. 2023. PMID: 37899701 Free PMC article.
Conversely, the expression of sterol regulatory element-binding protein 1 (SREBP1) was elevated (+91%, P = 0.007; +51%, P = 0.03 compared with control and NaHS-treated mice, respectively), along with diacylglycerol O-acyltransferase 1 (DGAT1) (+95%, P = 0.001; +35%, P = 0.02) and …
Conversely, the expression of sterol regulatory element-binding protein 1 (SREBP1) was elevated (+91%, P = 0.007; +51%, P = 0.03 compared wi …
Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer.
Peng Y, Lei X, Yang Q, Zhang G, He S, Wang M, Ling R, Zheng B, He J, Chen X, Li F, Zhou Q, Zhao L, Ye G, Li G. Peng Y, et al. Exp Mol Med. 2024 Feb;56(2):441-452. doi: 10.1038/s12276-024-01167-5. Epub 2024 Feb 21. Exp Mol Med. 2024. PMID: 38383581 Free PMC article.
Mechanistically, CagA promotes the synthesis of polyunsaturated ether phospholipids (PUFA-ePLs), which is mediated by increased expression of alkylglycerone phosphate synthase (AGPS) and 1-acylglycerol-3-phosphate O-acyltransferase 3 (AGPAT3), leading to susceptibility to …
Mechanistically, CagA promotes the synthesis of polyunsaturated ether phospholipids (PUFA-ePLs), which is mediated by increased expression o …
Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.
Prasad SS, Garg A, Agarwal AK. Prasad SS, et al. J Lipid Res. 2011 Mar;52(3):451-62. doi: 10.1194/jlr.M007575. Epub 2010 Dec 20. J Lipid Res. 2011. PMID: 21173190 Free PMC article.
AGPAT5-GFP fusion protein was localized in the mitochondria of both Chinese hamster ovary and human epithelial cervical cancer cells. Using lysates of AD293 cells infected with AGPAT3 and AGPAT5 recombinant adenovirus, we show that AGPAT3 and AGPAT5 proteins have AG …
AGPAT5-GFP fusion protein was localized in the mitochondria of both Chinese hamster ovary and human epithelial cervical cancer cells. Using …
Whole genome analysis of rare deleterious variants adds further evidence to BRSK2 and other risk genes in Autism Spectrum Disorder.
Bacchelli E, Viggiano M, Ceroni F, Visconti P, Posar A, Scaduto M, Sandoni L, Baravelli I, Cameli C, Rochat M, Maresca A, Vaisfeld A, Gentilini D, Calzari L, Carelli V, Zody M, Maestrini E. Bacchelli E, et al. Res Sq [Preprint]. 2023 Oct 28:rs.3.rs-3468592. doi: 10.21203/rs.3.rs-3468592/v1. Res Sq. 2023. PMID: 37961520 Free PMC article. Updated. Preprint.
Moreover, the identification of 9 severe de novo pdSNVs in genes not previously implicated in ASD (RASAL2, RAP1A, IRX5, SLC9A1, AGPAT3, MGAT3, RAB8B, MGAT5B, YME1L1), highlighted novel candidates. ...
Moreover, the identification of 9 severe de novo pdSNVs in genes not previously implicated in ASD (RASAL2, RAP1A, IRX5, SLC9A1, AGPAT3 …
44 results