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Ann Hematol. 2018 Jan;97(1):31-49. doi: 10.1007/s00277-017-3183-7. Epub 2017 Nov 24.

Diagnosis and management of gastrointestinal complications in adult cancer patients: 2017 updated evidence-based guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).

Author information

1
Clinic for Hematology, Oncology, Tumor Immunology and Palliative Care, HELIOS Klinikum Berlin-Buch, Berlin, Germany.
2
Deutsches Beratungszentrum für Hygiene, BZH GmbH, Freiburg, Germany.
3
3rd Department of Internal Medicine - Hematology and Oncology - Mannheim University Hospital, University of Heidelberg, Heidelberg, Germany.
4
1st Department of Internal Medicine, University of Cologne, Cologne, Germany.
5
German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany.
6
Clinical Trials Centre Cologne, ZKS Köln, University of Cologne, Cologne, Germany.
7
Department III for Internal Medicine, Hematology and Oncology, Rotkreuzklinikum München, Munich, Germany.
8
Department of Hematology, Oncology and Palliative Care, Ernst-von-Bergmann Klinikum, Potsdam, Germany.
9
Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Magdeburg, Germany.
10
1st Department of Internal Medicine, University of Cologne, Cologne, Germany. maria.vehreschild@uk-koeln.de.
11
German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany. maria.vehreschild@uk-koeln.de.
12
1st Department of Internal Medicine, Hospital of the University of Cologne, Kerpener Str. 62, 50937, Köln, Germany. maria.vehreschild@uk-koeln.de.

Abstract

Cancer patients frequently suffer from gastrointestinal complications. In this manuscript, we update our 2013 guideline on the diagnosis and management of gastrointestinal complications in adult cancer patients by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). An expert group was put together by the AGIHO to update the existing guideline. For each sub-topic, a literature search was performed in PubMed, Medline, and Cochrane databases, and strengths of recommendation and the quality of the published evidence for major therapeutic strategies were categorized using the 2015 European Society for Clinical Microbiology and Infectious Diseases (ESCMID) criteria. Final recommendations were approved by the AGIHO plenary conference. Recommendations were made with respect to non-infectious and infectious gastrointestinal complications. Strengths of recommendation and levels of evidence are presented. A multidisciplinary approach to the diagnosis and management of gastrointestinal complications in cancer patients is mandatory. Evidence-based recommendations are provided in this updated guideline.

KEYWORDS:

Abdominal complications; Cancer; Chemotherapy; Colitis; Diarrhea; Infection

PMID:
29177551
PMCID:
PMC5748412
DOI:
10.1007/s00277-017-3183-7
[Indexed for MEDLINE]
Free PMC Article

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