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AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K. Welcker D, et al. Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11. Oncogene. 2018. PMID: 29321668
Here, we show that replication stress occurs in Kras-driven murine lung adenocarcinomas, as well as in proliferating murine embryonic and adult tissues. We identify the transcriptional regulator AATF/CHE-1 as a key molecule to sustain proliferative tissues and tumor …
Here, we show that replication stress occurs in Kras-driven murine lung adenocarcinomas, as well as in proliferating murine embryonic …
The PI3K/AKT axis modulates AATF activity in Wilms' tumor cells.
Jing P, Zou J, Weng K, Peng P. Jing P, et al. FEBS Open Bio. 2018 Sep 4;8(10):1615-1623. doi: 10.1002/2211-5463.12500. eCollection 2018 Oct. FEBS Open Bio. 2018. PMID: 30338213 Free PMC article. Retracted.
Previous studies have reported excessive expression of apoptosis-antagonizing transcription factor (AATF) in various tumors, where it reinforces the generation and development of cancers and is linked to the clinical outcome. ...Proliferation, invasion, and m …
Previous studies have reported excessive expression of apoptosis-antagonizing transcription factor (AATF) in various tumors, w …
The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response.
Passananti C, Fanciulli M. Passananti C, et al. Cell Div. 2007 Jul 16;2:21. doi: 10.1186/1747-1028-2-21. Cell Div. 2007. PMID: 17634135 Free PMC article.
Che-1 is a RNA polymerase II binding protein involved in the transcriptional regulation of E2F target genes and in cell proliferation. Recently, it has been shown that Che-1 accumulates in cells responding to genotoxic agents such as Doxorubicin and ionizing radiation. ... …
Che-1 is a RNA polymerase II binding protein involved in the transcriptional regulation of E2F target genes and in cell proliferation
Che-1: a new effector of checkpoints signaling.
Floridi A, Fanciulli M. Floridi A, et al. Cell Cycle. 2007 Apr 1;6(7):804-6. doi: 10.4161/cc.6.7.4043. Epub 2007 Apr 22. Cell Cycle. 2007. PMID: 17377493 Review.
Che-1 is a RNA polymerase II binding protein involved in the transcriptional regulation of E2F target-genes and in cell proliferation. Recently, it has been shown that Che-1 accumulates in cells responding to genotoxic agents, such as Doxorubicin and ionizing radiations. . …
Che-1 is a RNA polymerase II binding protein involved in the transcriptional regulation of E2F target-genes and in cell proliferation
Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression.
Liu M, Wang D, Li N. Liu M, et al. Biochem Biophys Res Commun. 2016 Apr 22;473(1):168-173. doi: 10.1016/j.bbrc.2016.03.073. Epub 2016 Mar 21. Biochem Biophys Res Commun. 2016. PMID: 27012205
MTT and flow cytometry assays showed that Che-1 depletion by siRNA markedly suppressed MG-63 and U2OS cell proliferation and promoted apoptosis. ...Notably, our study showed that the loss of Che-1 inhibits proliferation and promotes ap
MTT and flow cytometry assays showed that Che-1 depletion by siRNA markedly suppressed MG-63 and U2OS cell proliferation and …