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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 4
2003 5
2004 3
2005 2
2006 3
2007 1
2008 4
2009 1
2010 1
2011 3
2012 5
2013 3
2014 4
2015 3
2016 6
2017 7
2018 6
2019 13
2020 19
2021 16
2022 17
2023 27
2024 8

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145 results

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Extracellular vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-kappaB axis.
Lian J, Zhu X, Du J, Huang B, Zhao F, Ma C, Guo R, Zhang Y, Ji L, Yahaya BH, Lin J. Lian J, et al. Mol Ther. 2023 May 3;31(5):1365-1382. doi: 10.1016/j.ymthe.2023.01.025. Epub 2023 Feb 2. Mol Ther. 2023. PMID: 36733250
Disruption of this abundantly expressed miR-671-5p dramatically reduced the ameliorative effect of extracellular vesicles released by menstrual blood-derived stem cells on lipopolysaccharide (LPS)-induced pulmonary inflammatory injury. Mechanistically, miR-671-5p directly targets …
Disruption of this abundantly expressed miR-671-5p dramatically reduced the ameliorative effect of extracellular vesicles released by menstr …
Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents.
Yuan YH, Mao ND, Duan JL, Zhang H, Garrido C, Lirussi F, Gao Y, Xie T, Ye XY. Yuan YH, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2279906. doi: 10.1080/14756366.2023.2279906. Epub 2023 Nov 13. J Enzyme Inhib Med Chem. 2023. PMID: 37955299 Free PMC article. Review.
Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr kinases, is a specific key kinase regulating Thr156 phosphorylation at the mu2 subunit of the adapter complex-2 (AP-2) protein. ...The aim is to provide the medicinal chemistry community with u …
Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr kinases, is a specific key kinase regulating Thr156 p …
A patent review of adaptor associated kinase 1 (AAK1) inhibitors (2013-present).
Martinez-Gualda B, Schols D, De Jonghe S. Martinez-Gualda B, et al. Expert Opin Ther Pat. 2021 Oct;31(10):911-936. doi: 10.1080/13543776.2021.1928637. Epub 2021 May 21. Expert Opin Ther Pat. 2021. PMID: 33971786 Review.
More recently, AAK1 was shown to be an essential cellular factor for viral replication and therefore has been pursued as a host target for the development of broad-spectrum antiviral agents. AREAS COVERED: This review provides an overview of the patented AAK1 inhibi …
More recently, AAK1 was shown to be an essential cellular factor for viral replication and therefore has been pursued as a host targe …
A common variant in AAK1 reduces risk of noise-induced hearing loss.
Wang Q, Wang X, Yang T, Yang L, Liu H, Zheng Y, Jiang G, Liu H, Huang C, Chen J, Wang Z, Wang Z, Zhao W, Lin J, Zhang X, Shi J, Han K, Le X, Ren Y, Li Y, Hong Y, Shi W, Cui D, Qian M, Xu J, Zheng X, Gao Y, Li C, Lin J, Huang Z, Wu H. Wang Q, et al. Natl Sci Rev. 2023 Mar 20;10(7):nwad080. doi: 10.1093/nsr/nwad080. eCollection 2023 Jul. Natl Sci Rev. 2023. PMID: 37547059 Free PMC article. No abstract available.
AAK1-like: A putative pseudokinase with potential roles in cargo uptake in bloodstream form Trypanosoma brucei parasites.
Black JA, Klinger CM, Lemgruber L, Dacks JB, Mottram JC, McCulloch R. Black JA, et al. J Eukaryot Microbiol. 2023 Nov-Dec;70(6):e12994. doi: 10.1111/jeu.12994. Epub 2023 Aug 7. J Eukaryot Microbiol. 2023. PMID: 37548427 Free PMC article.
African trypanosomes lack all components of the AP-2 complex, except for a recently identified orthologue of the AP-2-associated protein kinase 1, AAK1. In characterized eukaryotes, AAK1 phosphorylates the mu2 subunit of the AP-2 complex to enhance cargo recognition …
African trypanosomes lack all components of the AP-2 complex, except for a recently identified orthologue of the AP-2-associated protein kin …
M2 Microglia Extracellular Vesicle miR-124 Regulates Neural Stem Cell Differentiation in Ischemic Stroke via AAK1/NOTCH.
Song Y, Shi R, Liu Y, Cui F, Han L, Wang C, Chen T, Li Z, Zhang Z, Tang Y, Yang GY, Guan Y. Song Y, et al. Stroke. 2023 Oct;54(10):2629-2639. doi: 10.1161/STROKEAHA.122.041611. Epub 2023 Aug 10. Stroke. 2023. PMID: 37586072
The binding of AAK1 to Notch promoted the differentiation of NSCs into neurons rather than astrocytes. CONCLUSIONS: Our data suggest that AAK1/Notch is the key pathway in NSCs that responds to the miR-124 carried within M2-sEVs in the ischemic brain. ...
The binding of AAK1 to Notch promoted the differentiation of NSCs into neurons rather than astrocytes. CONCLUSIONS: Our data suggest …
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
Wells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-de-Sousa RR, Willson TM, Zhang C, Zuercher WJ, Zutshi R, Axtman AD. Wells C, et al. ACS Med Chem Lett. 2019 Oct 23;11(3):340-345. doi: 10.1021/acsmedchemlett.9b00399. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184967 Free PMC article.
Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnished a small molecule chemical probe (SGC-AAK1-1, 25) that is potent and selective for AAK1/BMP2K over other NAK family members, …
Inhibitors based on a 3-acylaminoindazole scaffold were synthesized to yield potent dual AAK1/BMP2K inhibitors. Optimization furnishe …
AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin.
Conner SD, Schröter T, Schmid SL. Conner SD, et al. Traffic. 2003 Dec;4(12):885-90. doi: 10.1046/j.1398-9219.2003.0142.x. Traffic. 2003. PMID: 14617351 Free article.
These results suggested that AAK1 might be tightly regulated in the cell. Here, we report that AAK1 is an atypical kinase that is rate limited by its stable association with AP2 and that clathrin stimulates micro2 phosphorylation by AAK1. Efficient stimulatio …
These results suggested that AAK1 might be tightly regulated in the cell. Here, we report that AAK1 is an atypical kinase that …
Development of a novel AAK1 inhibitor via Kinobeads-based screening.
Yoshida A, Ohtsuka S, Matsumoto F, Miyagawa T, Okino R, Ikeda Y, Tada N, Gotoh A, Magari M, Hatano N, Morishita R, Satoh A, Sunatsuki Y, Nilsson UJ, Ishikawa T, Tokumitsu H. Yoshida A, et al. Sci Rep. 2024 Mar 20;14(1):6723. doi: 10.1038/s41598-024-57051-9. Sci Rep. 2024. PMID: 38509168 Free PMC article.
A chemical proteomics approach using Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor-immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKalpha/1 and beta/2, and potential off-target kinases, including AP2-associated protein kinase 1 …
A chemical proteomics approach using Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor-immobilized sepharose (TIM-063-Kino …
Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling.
Yuan C, Ai K, Xiang M, Xie C, Zhao M, Wu M, Li H, Wu Y, Cao Y, Li C, Zhong Y, Pei X, Law HKW, Gao L, Xiao Q, Yang X. Yuan C, et al. Cell Death Dis. 2022 Aug 18;13(8):722. doi: 10.1038/s41419-022-05151-7. Cell Death Dis. 2022. PMID: 35982051 Free PMC article.
The in-vitro study both in physics and physiology showed that PHZ-OH targeted AP2-associated protein kinase 1 (AAK1) and thus prevented AAK1-mediated LPS internalization for caspase-11 activation. ...Besides, PHZ-OH showed additional protection on Nlrp3(-/-) and Cas …
The in-vitro study both in physics and physiology showed that PHZ-OH targeted AP2-associated protein kinase 1 (AAK1) and thus prevent …
145 results