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Diabetes Metab Syndr. 2018 Sep;12(5):683-687. doi: 10.1016/j.dsx.2018.04.006. Epub 2018 Apr 12.

A study of difference in serum 25-hydroxyvitamin D concentrations in patients with angiographically-defined coronary disease and healthy subjects.

Author information

1
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran; Department of Modern Sciences and Technologies, School Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Modern Sciences and Technologies, School Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Endocrine Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
6
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
7
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.

Abstract

BACKGROUND:

Cardiovascular disease (CVD) is one of the most important causes of death in developing countries. The current study evaluates the serum 25-hydroxyvitamin D (25OHD), phosphate and calcium levels in patients with angiographically-defined coronary artery disease (CAD) and healthy subjects in a sample population in northeastern Iran.

METHODS:

There were 566 subjects aged between 20-80 years out of whom283 subjects with CAD were divided into two study groups based on their angiogram results; those with > 50% stenosis of one or more coronary arteries and those with ≤ 50% stenosis. Serum 25OHD levels and anthropometric parameters were measured for all subjects.

RESULTS:

There were approximately 53% (n = 303) males and 47% (n = 269) females in the population sample. We found that crude serum 25OHD concentrations were significantly higher in both the Angio- (21.6 ± 11.8 ng/ml) and Angio+ (21.3 ± 10.2 ng/ml) groups compared to the control subjects (16.4 ± 9.5 ng/ml) (P < 0.001).

CONCLUSION:

The findings show that 25OHD state could be a risk factor for CAD, although this would need to be explored further, taking the potential confounding effects of diet into account in future studies.

KEYWORDS:

25OHD; Angiography; Calcium; Coronary artery disease; Phosphate

PMID:
29680517
DOI:
10.1016/j.dsx.2018.04.006
[Indexed for MEDLINE]

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