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Oncotarget. 2016 Oct 18;7(42):68434-68441. doi: 10.18632/oncotarget.12034.

A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head.

Author information

1
Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.
2
Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
3
The College of Life Sciences Northwest University, 710069, China.

Abstract

Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the "CGC" MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.

KEYWORDS:

MMP2; MMP9; association study; osteonecrosis of the femoral head; single nucleotide polymorphisms

PMID:
27637086
PMCID:
PMC5356565
DOI:
10.18632/oncotarget.12034
[Indexed for MEDLINE]
Free PMC Article

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