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Oncotarget. 2016 Oct 18;7(42):68434-68441. doi: 10.18632/oncotarget.12034.

A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head.

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Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.
Department of Orthopedics and Traumatology, The 2th Affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, 010030, China.
The College of Life Sciences Northwest University, 710069, China.


Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the "CGC" MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.


MMP2; MMP9; association study; osteonecrosis of the femoral head; single nucleotide polymorphisms

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