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IUBMB Life. 2015 Jul;67(7):564-74. doi: 10.1002/iub.1403. Epub 2015 Jul 14.

A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts.

Author information

1
Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, 121 001, India.
2
Manipal University, Manipal.Edu, Manipal, 576104, Karnataka, India.

Abstract

Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides--termed as DNA lesions. The N(2) -atom of deoxyguanosine is particularly reactive and a number of chemicals react at this site to form different kinds of DNA adducts. The N(2) -deoxyguanosine adducts perturb different genomic processes and are particularly deleterious for DNA replication as they have a strong tendency to inhibit replicative DNA polymerases. Many organisms possess specialized dPols--generally classified in the Y-family--that serves to rescue replication stalled at N(2) -dG and other adducts. A review of minor groove N(2) -adducts and the known strategies utilized by Y-family dPols to replicate past these lesions will be presented here.

KEYWORDS:

DNA polymerase; DNA replication; N2-adducts; translesion DNA synthesis

PMID:
26173005
DOI:
10.1002/iub.1403
[Indexed for MEDLINE]
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