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Bipolar Disord. 2015 Nov;17(7):689-704. doi: 10.1111/bdi.12331. Epub 2015 Sep 19.

A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force.

Author information

1
Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA.
2
Bipolar Disorder Program, Neurosciences Institute, Favaloro University, Buenos Aires, Argentina.
3
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA.
4
Department of Old Age Psychiatry, GGZ inGeest, EMGO Institute of Care and Health Research, VU University Medical Center, Amsterdam, the Netherlands.
5
Michael E. DeBakey VA Medical Center, Houston, TX, USA.
6
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
7
Division of Geriatric Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA, USA.
8
Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
9
Duke University Medical Center, Durham, NC, USA.
10
Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina.
11
Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina.
12
UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile.
13
National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
14
Australian Research Council (ACR) Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW, Australia.
15
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
16
Geri PARTy Research Group, Jewish General Hospital, Montreal, QC, Canada.
17
Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
18
Department of Pharmacology, Laboratory of Molecular Psychiatry, INCT for Translational Medicine-CNPq, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
19
Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan.
20
Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
21
Weill Cornell Medical College and New York Presbyterian Hospital, White Plains, NY, USA.
22
Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Abstract

OBJECTIVES:

In the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD).

METHODS:

This task force report addresses the unique aspects of OABD including epidemiology and clinical features, neuropathology and biomarkers, physical health, cognition, and care approaches.

RESULTS:

The report describes an expert consensus summary on OABD that is intended to advance the care of patients, and shed light on issues of relevance to BD research across the lifespan. Although there is still a dearth of research and health efforts focused on older adults with BD, emerging data have brought some answers, innovative questions, and novel perspectives related to the notion of late onset, medical comorbidity, and the vexing issue of cognitive impairment and decline.

CONCLUSIONS:

Improving our understanding of the biological, clinical, and social underpinnings relevant to OABD is an indispensable step in building a complete map of BD across the lifespan.

KEYWORDS:

bipolar disorder; cognition; elderly; geriatric; manic depressive disorder; mood stabilizers

PMID:
26384588
PMCID:
PMC4623878
DOI:
10.1111/bdi.12331
[Indexed for MEDLINE]
Free PMC Article

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