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Transfusion. 2016 Sep;56(9):2391-2. doi: 10.1111/trf.13679. Epub 2016 Jun 10.

A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens.

Author information

1
Clinical Immunology and Transfusion Medicine, Region Skåne, Lund, Sweden.
2
Clinical Immunology and Transfusion Medicine, Region Skåne, Lund, Sweden. jill.storry@med.lu.se.

Abstract

We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.

PMID:
27282785
DOI:
10.1111/trf.13679
[Indexed for MEDLINE]

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