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Eur J Prev Cardiol. 2018 Apr;25(6):642-650. doi: 10.1177/2047487317752948. Epub 2018 Feb 7.

A new selection method to increase the health benefits of CVD prevention strategies.

Author information

1
1 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
2
2 Netherlands Heart Institute, The Netherlands.
3
3 Center for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, The Netherlands.
4
4 Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands.
5
5 Department of Health Technology and Services Research, University of Twente, The Netherlands.

Abstract

Background Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of CVD events may be larger in younger individuals. The purpose of this paper is to investigate if health benefits from preventive treatment may increase when the selection strategy is further optimised. Methods Data from three Dutch cohorts were combined ( nā€‰=ā€‰47469, men:women 1:1.92) and classified into subgroups based on age and gender. The Framingham global risk score was used to estimate 10-year CVD risk. The associated lifelong burden of CVD events according to this 10-year CVD risk was expressed as quality-adjusted life years lost. Based on this approach, the additional health benefits from preventive treatment, reducing this 10-year CVD risk, from selecting individuals based on their expected CVD burden rather than their expected CVD risk were estimated. These benefits were expressed as quality-adjusted life years gained over lifetime. Results When using the current selection strategy (10% risk threshold), 32% of the individuals were selected for preventive treatment. When the same proportion was selected based on burden, more younger and fewer older individuals would receive treatment. Across all individuals, the gain in quality-adjusted life years was 217 between the two strategies, over a 10-year time horizon. In addition, when combining the strategies 5% extra eligible individuals were selected resulting in a gain of 628 quality-adjusted life years. Conclusion Improvement of the selection approach of individuals can help to reduce further the CVD burden. Selecting individuals for preventive treatment based on their expected CVD burden will provide more younger and fewer older individuals with treatment, and will reduce the overall CVD burden.

KEYWORDS:

Cardiovascular disease; burden of disease; prevention; public health; risk prediction

PMID:
29411690
PMCID:
PMC5946653
DOI:
10.1177/2047487317752948
[Indexed for MEDLINE]
Free PMC Article

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