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Planta Med. 2007 Oct;73(13):1412-5. Epub 2007 Oct 11.

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

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1
Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan, ROC.

Erratum in

  • Planta Med. 2007 Nov;73(14):1522.

Abstract

Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM.

PMID:
17932820
DOI:
10.1055/s-2007-990232
[Indexed for MEDLINE]

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