Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Reprod Toxicol. 2018 Apr;77:25-32. doi: 10.1016/j.reprotox.2018.02.002. Epub 2018 Feb 6.

A utilitarian comparison of two alcohol use biomarkers with self-reported drinking history collected in antenatal clinics.

Author information

1
University of North Carolina at Chapel Hill, Nutrition Research Institute, United States; Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch 7600, South Africa. Electronic address: philip_may@unc.edu.
2
University of North Carolina at Chapel Hill, Nutrition Research Institute, United States.
3
Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch 7600, South Africa.
4
Fulbright U.S. Student, 2015, Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch 7600, South Africa.
5
Stellenbosch University, Faculty of Medicine and Health Sciences, Stellenbosch 7600, South Africa; Alcohol, Tobacco, and Other Drug Research Unit, South African Medical Research Council, Cape Town, 7501, South Africa.
6
California State University, Northridge, CA 90802, United States.

Abstract

BACKGROUND:

Alcohol use is reported accurately among pregnant women in some populations.

METHODS:

Self-reported alcohol use via the AUDIT and 90-day recall for 193 women from antenatal clinics was compared to biomarker results: phosphatidylethanol (PEth) from bloodspots and ethyl glucuronide (EtG) in fingernails.

RESULTS:

AUDIT was positive for 67.9% of respondents, and 65.3% directly reported drinking. Individual biomarkers detected less drinking (PEth = 57.0%, EtG = 38.9%) than self-report. But 64.8% had drinking-positive values (>8 ng) on one or both biomarkers, which was not significantly different from self-report. Biomarkers indicated that 3.1% -6.8% of drinkers denied drinking. Combined biomarker sensitivity was 95% -80% and specificity 49% -76% for drinking in the previous 7-90 days. Combined biomarker results have their best yield (89.6%) and accuracy (78.8%) when measuring 90 day drinking.

CONCLUSIONS:

Women reported their alcohol use accurately, and the combined use of PEth and EtG is supported.

KEYWORDS:

AUDIT; Alcohol; Biomarkers of alcohol use; Ethyl glucuronide (EtG); Phosphatidylethanol (PEth); Quantity and frequency of drinking; Self-report of alcohol use

PMID:
29425712
PMCID:
PMC5878131
[Available on 2019-04-01]
DOI:
10.1016/j.reprotox.2018.02.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center