Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Structure. 2014 Jan 7;22(1):1-2. doi: 10.1016/j.str.2013.12.006.

A small switch has a large effect on autophagy.

Author information

1
University Grenoble Alpes, 38000 Grenoble, France; CNRS, UVHCI, 38000 Grenoble, France; Unit of Virus Host-Cell Interactions, University Grenoble Alpes-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble, France. Electronic address: weissenhorn@embl.fr.
2
University Grenoble Alpes, 38000 Grenoble, France; INSERM, U1038, 38054 Grenoble, France; CEA, DSV, iRTSV, BGE, Gen&Chem, 38054 Grenoble, France. Electronic address: mofauvarque@cea.fr.

Abstract

Atg8 family proteins and Atg13 are important regulators of autophagy. In this issue of Structure, Suzuki and colleagues describe crystal structures of light chain 3 (LC3; Atg8) in complex with the Atg13 LC3 interacting region (LIR) motif and identify a subtle switch of side chain conformation regulating the LC3-LIR interaction and autophagosome formation in vivo.

PMID:
24411573
DOI:
10.1016/j.str.2013.12.006
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center