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Antimicrob Agents Chemother. 2015 Sep;59(9):5542-7. doi: 10.1128/AAC.00805-15. Epub 2015 Jun 29.

Preliminary method for direct quantification of colistin methanesulfonate by attenuated total reflectance Fourier transform infrared spectroscopy.

Author information

1
Department of Extremity Trauma and Regenerative Medicine, United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas, USA.
2
Department of Extremity Trauma and Regenerative Medicine, United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas, USA Infectious Disease Service, Department of Medicine, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas, USA kevin.s.akers.mil@mail.mil.

Abstract

Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing, and questions remain about the pharmacokinetics of CMS. Since CMS does not have strong UV absorbance, current methods employ a laborious process of chemical conversion to colistin followed by precolumn derivatization to detect formed colistin by high-performance liquid chromatography. Here, we report a method for direct quantification of colistin methanesulfonate by attenuated total reflectance Fourier transform infrared spectroscopy (ATR FTIR).

PMID:
26124160
PMCID:
PMC4538559
DOI:
10.1128/AAC.00805-15
[Indexed for MEDLINE]
Free PMC Article

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