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J Neurotrauma. 2016 Aug 25. doi: 10.1089/neu.2015.4124. [Epub ahead of print]

A New Approach to Evidence Synthesis in Traumatic Brain Injury: A Living Systematic Review.

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1 Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Australian and New Zealand Intensive Care Research Centre, Monash University , Melbourne, Australia .
2 Cochrane Consumers and Communication Review Group, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University , Melbourne, Australia .
11 National Trauma Research Institute, Alfred Hospital, Melbourne, Australia .
3 Central Clinical School, Monash University , Melbourne, Australia .
4 Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore .
5 University of Cambridge , Cambridge, United Kingdom .
6 Department of Public Health, Erasmus University Medical Center , Rotterdam, the Netherlands .
7 Department of Neurosurgery, University of Pécs and Clinical Neuroscience Image Center of Hungarian Academy of Sciences (HAS) , Pécs, Hungary .
8 Department of Neurosurgery, Leiden University Medical Centre and Medical Centre The Hague , The Hague and Leiden, the Netherlands .
9 Department of Infectious Diseases and Australasian Cochrane Centre, Monash University , Melbourne, Australia .
10 Department of Neurosurgery, University Hospital Antwerp and University of Antwerp , Antwerp, Belgium .


Living systematic reviews (LSRs) are online summaries of health care research that are updated as new research becomes available. This new development in evidence synthesis is being trialled as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project. We will develop and sustain an international TBI knowledge community that maintains up-to-date, high quality LSRs of the current state of knowledge in the most important questions in TBI. Automatic search updates will be run three-monthly, and newly identified studies incorporated into the review. Review teams will seek to publish journal updates at regular intervals, with abridged updates available more frequently online. Future project stages include the integration of LSR and other study findings into "living" clinical practice guidance. It is hoped these efforts will go some way to bridging current temporal disconnects between evidence, guidelines, and practice in TBI.


knowledge translation; living systematic reviews; traumatic brain injury


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