Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Rejuvenation Res. 2016 Dec;19(6):478-484. Epub 2016 Mar 30.

A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study.

Author information

1
1 Anti-aging Group Barcelona , Barcelona, Spain .
2
2 T.A. Sciences, Inc. , New York, New York.
3
3 Independent Consultant , Murphys, California.
4
4 Peter Flom Consulting , New York, New York.
5
5 PhysioAge Systems, LLC , New York, New York.

Abstract

TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 ± 180 bp; p = 0.005), whereas subjects in the placebo group significantly lost TL (290 ± 100 bp; p = 0.01). The high dose of TA-65 (1000 U) showed a trend of improvements in TL compared with that of the placebo group; however, the improvements did not reach statistical significance. TL changes in the low-dose group were similar for both median and 20th percentile TLs. The findings suggest that TA-65 can lengthen telomeres in a statistically and possibly clinically significant manner.

KEYWORDS:

Astragalus; TA-65; placebo controlled trial; randomized; telomerase; telomere length

PMID:
26950204
PMCID:
PMC5178008
DOI:
10.1089/rej.2015.1793
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center