Format

Send to

Choose Destination

See 1 citation found by title matching your search:

J Gerontol A Biol Sci Med Sci. 2016 Jun;71(6):703-12. doi: 10.1093/gerona/glv141. Epub 2015 Sep 9.

A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans.

Author information

1
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles. melevine@mednet.ucla.edu.
2
Davis School of Gerontology, University of Southern California, Los Angeles.

Abstract

Human longevity and diseases are likely influenced by multiple interacting genes within a few biologically conserved pathways. Using long-lived smokers as a phenotype (n = 90)-a group whose survival may signify innate resilience-we conducted a genome-wide association study comparing them to smokers at ages 52-69 (n = 730). These results were used to conduct a functional interaction network and pathway analysis, to identify single nucleotide polymorphisms that collectively related to smokers' longevity. We identified a set of 215 single nucleotide polymorphisms (all of which had p <5×10(-3) in the genome-wide association study) that were located within genes making-up a functional interaction network. These single nucleotide polymorphisms were then used to create a weighted polygenic risk score that, using an independent validation sample of nonsmokers (N = 6,447), was found to be significantly associated with a 22% increase in the likelihood of being aged 90-99 (n = 253) and an over threefold increase in the likelihood of being a centenarian (n = 4), compared with being at ages 52-79 (n = 4,900). Additionally, the polygenic risk score was also associated with an 11% reduction in cancer prevalence over up to 18 years (odds ratio: 0.89, p = .011). Overall, using a unique phenotype and incorporating prior knowledge of biological networks, this study identified a set of single nucleotide polymorphisms that together appear to be important for human aging, stress resistance, cancer, and longevity.

KEYWORDS:

Cancer; Genetic network; HRS; Longevity; Polygenic risk score; Resilience

PMID:
26355015
PMCID:
PMC4888382
DOI:
10.1093/gerona/glv141
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center