Infections in IFNGR-1-deficient children

J Interferon Cytokine Res. 1997 Oct;17(10):583-7. doi: 10.1089/jir.1997.17.583.

Abstract

Human interferon-gamma receptor 1 (IFNGR-1) deficiency is a newly identified autosomal recessive inherited immune disorder. Children with IFNGR-1 deficiency exhibit a severe, profound and selective susceptibility to weakly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccine or environmental nontuberculous mycobacteria (NTM). This review compares the infections found in IFNGR-1-deficient children to those in IFN-gamma-deficient or IFNGR-1-deficient mice.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Infections / physiopathology
  • Child
  • Humans
  • Infections / physiopathology*
  • Interferon gamma Receptor
  • Interferon-gamma*
  • Mice
  • Parasitic Diseases / physiopathology
  • Receptors, Interferon / deficiency*
  • Virus Diseases / physiopathology

Substances

  • Receptors, Interferon
  • Interferon-gamma