Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma

I Takanami; F Tanaka; T Hashizume; S Kodaira

Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma

Anticancer Res. 1997 Jul-Aug;17(4A):2811-4.

Authors

I Takanami¹, F Tanaka, T Hashizume, S Kodaira

Affiliation

¹ First Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.

PMID: 9252720

Abstract

The vascular endothelial growth factor (VEGF) and its receptor (Flt) protein expression was immunologically studied individually and in combination with the microvascular density (MVD) determined by the factor 8-related antigen (F8RA) and their prognostic value in 118 patients with a pulmonary adenocarcinoma. The presence of VEGF and Flt was associated with the MVD and prognosis. A reduced expression of both of VEGF and Flt correlated with less tumor angiogenesis and a better prognosis. Our findings suggest that VEGF and Flt expressions play an important role in tumor angiogenesis and that the VEGF and Flt coexpression promotes angiogenesis and metastasis in pulmonary adenocarcinoma.

MeSH terms

Adenocarcinoma / physiopathology*
Adult
Aged
Endothelial Growth Factors / metabolism*
Female
Humans
Immunohistochemistry
Lung Neoplasms / physiopathology*
Lymphokines / metabolism*
Male
Middle Aged
Neovascularization, Pathologic / physiopathology*
Receptor Protein-Tyrosine Kinases / metabolism*
Receptors, Growth Factor / metabolism*
Receptors, Vascular Endothelial Growth Factor
Survival Analysis
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
von Willebrand Factor / metabolism

Substances

Endothelial Growth Factors
Lymphokines
Receptors, Growth Factor
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
von Willebrand Factor
Receptor Protein-Tyrosine Kinases
Receptors, Vascular Endothelial Growth Factor