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Scand J Gastroenterol Suppl. 1997;222:62-4. doi: 10.1080/00365521.1997.11720721.

Effect of lactulose on carbohydrate metabolism and diabetes mellitus.

Author information

1
Institute of Internal Medicine, University of Bologna, Italy.

Abstract

BACKGROUND:

Unabsorbable disaccharides, by reducing transit time and possibly glucose absorption, are expected to affect carbohydrate metabolism.

AIM:

To test the effects of a preparation containing fibre and lactulose in the form of biscuits on glucose and insulin levels in obesity.

METHODS:

In 10 obese patients glucose and insulin were measured in the fasting state and in response to a meal during two consecutive days on a strictly controlled diet; on one day a total of 11 biscuits (10 g dietary fibre, 2 g raw fibre +8.2 g lactulose) were randomly substituted for an equicaloric part of a diet.

RESULTS:

Glucose and insulin in response to breakfast and to lunch were blunted by dietary fibre and lactulose, without any trend towards post-meal hypoglycaemia. Average day-time glucose decreased by 0.53 +/- SD 0.28 mmol/L, and insulin by 74.6 +/- 45.2 pmol/L. Plasma amino acids were higher during supplementation, ruling out malabsorption as a cause of glucose flattening.

CONCLUSION:

Because of the rationale of the preparation, good compliance of patients, and significant results in short-term experiments, the association of fibre and lactulose deserves more careful evaluation in long-term clinical studies.

PMID:
9145450
DOI:
10.1080/00365521.1997.11720721
[Indexed for MEDLINE]

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