Format

Send to

Choose Destination
Science. 1997 Mar 7;275(5305):1481-5.

Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.

Author information

1
The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.

Abstract

Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients. Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors. Expression of the HIV-1 transactivator Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28. IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.

PMID:
9045614
DOI:
10.1126/science.275.5305.1481
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center