Serum levels of GM-CSF are elevated in patients with thrombocytopenia

Br J Haematol. 1996 Feb;92(2):486-8. doi: 10.1046/j.1365-2141.1996.d01-1464.x.

Abstract

Serum levels of GM-CSF, IL-3 and IL-6 were measured in patients with immune thrombocytopenia (ITP), non-immune thrombocytopenia (NIT), autoimmune haemolytic anaemia (AIHA) and neutropenia. 8/10 children with ITP had elevated serum levels of GM-CSF (mean 18.4 pg/ml) while thrombocytopenic, but only two had detectable levels (mean 4.5 pg/ml) after normalization of the platelet count. In patients with NIT a significant inverse correlation between platelet count and serum levels of GM-CSF was observed. IL-3 and IL-6 levels were not significantly elevated in thrombocytopenic patients and only two of the nine patients with either AIHA or neutropenia had detectable levels of GM-CSF. Thus, GM-CSF may play a role in the response of severe thrombocytopenia.

MeSH terms

  • Adolescent
  • Anemia, Hemolytic / blood
  • Autoimmune Diseases / blood
  • Child
  • Child, Preschool
  • Female
  • Granulocyte-Macrophage Colony-Stimulating Factor / blood*
  • Humans
  • Interleukin-3 / blood
  • Interleukin-6 / blood
  • Male
  • Neutropenia / blood
  • Thrombocytopenia / blood*

Substances

  • Interleukin-3
  • Interleukin-6
  • Granulocyte-Macrophage Colony-Stimulating Factor