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FEBS Lett. 1993 Jun 21;324(3):293-5.

An interaction of beta-amyloid with aluminium in vitro.

Author information

1
Department of Chemistry, Keele University, Staffordshire, UK.

Abstract

We have used circular dichroism spectroscopy to confirm that, in a membrane-mimicking solvent, A beta P(1-40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and beta-amyloid and may have important implications for the pathogenesis of Alzheimer's disease.

PMID:
8405368
DOI:
10.1016/0014-5793(93)80137-j
[Indexed for MEDLINE]
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