Cytomegalovirus polyradiculopathy caused by a ganciclovir-resistant strain

Clin Infect Dis. 1993 Nov;17(5):854-6. doi: 10.1093/clinids/17.5.854.

Abstract

Polyradiculopathy caused by cytomegalovirus (CMV) is a rare but serious neurological disorder that occurs late in the course of HIV-1 infection and is potentially treatable with antimicrobial agents active against CMV. We describe a patient with CMV infection caused by a strain that was resistant to ganciclovir. This case demonstrates one potential mechanism of therapeutic failure and illustrates the potential pathogenicity of strains that are resistant to antiviral drugs.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / complications*
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / microbiology
  • Adult
  • Cytomegalovirus / drug effects
  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / microbiology
  • Cytomegalovirus Retinitis / complications
  • Cytomegalovirus Retinitis / drug therapy
  • Drug Resistance, Microbial
  • Ganciclovir / therapeutic use
  • HIV-1*
  • Humans
  • Male
  • Polyradiculopathy / complications*
  • Polyradiculopathy / drug therapy
  • Polyradiculopathy / microbiology

Substances

  • Ganciclovir