Abstract
Polyradiculopathy caused by cytomegalovirus (CMV) is a rare but serious neurological disorder that occurs late in the course of HIV-1 infection and is potentially treatable with antimicrobial agents active against CMV. We describe a patient with CMV infection caused by a strain that was resistant to ganciclovir. This case demonstrates one potential mechanism of therapeutic failure and illustrates the potential pathogenicity of strains that are resistant to antiviral drugs.
MeSH terms
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AIDS-Related Opportunistic Infections / complications*
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / microbiology
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Adult
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Cytomegalovirus / drug effects
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Cytomegalovirus Infections / complications*
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Cytomegalovirus Infections / drug therapy
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Cytomegalovirus Infections / microbiology
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Cytomegalovirus Retinitis / complications
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Cytomegalovirus Retinitis / drug therapy
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Drug Resistance, Microbial
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Ganciclovir / therapeutic use
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HIV-1*
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Humans
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Male
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Polyradiculopathy / complications*
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Polyradiculopathy / drug therapy
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Polyradiculopathy / microbiology