Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1994 Jan 28;198(2):531-5.

Aluminum promotes the aggregation of Alzheimer's amyloid beta-protein in vitro.

Author information

1
Department of Molecular & Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan.

Abstract

Amyloid beta-protein is the major component of senile plaques in the brains of Alzheimer's disease and has an intrinsic tendency to form insoluble aggregates. The aggregation of amyloid beta-protein has been suggested to enhance its neurotoxicity and to play a key role in the amyloid deposition. Here we show, using gel-electrophoresis and immunoblotting, that the aggregation of synthetic amyloid beta-protein (beta 1-40) is promoted by aluminum, a suspected risk factor in Alzheimer's disease. High molecular weight aggregates were observed, and the amount of precipitated protein was estimated using high performance liquid chromatography. The results suggest the possibility that aluminum directly influences the process of aggregation and the deposition of senile plaques.

PMID:
7507666
DOI:
10.1006/bbrc.1994.1078
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center