Renal necrosis, glutathione depletion, and covalent binding after acetaminophen

Toxicol Appl Pharmacol. 1978 Oct;46(1):87-100. doi: 10.1016/0041-008x(78)90139-4.
No abstract available

MeSH terms

  • Acetaminophen / metabolism
  • Acetaminophen / toxicity*
  • Animals
  • Chlorides / pharmacology
  • Cobalt / pharmacology
  • Dose-Response Relationship, Drug
  • Glutathione / metabolism
  • In Vitro Techniques
  • Kidney / drug effects*
  • Kinetics
  • Liver / drug effects*
  • Male
  • Methylcholanthrene / pharmacology
  • Microsomes / drug effects
  • Protein Binding
  • Rats

Substances

  • Chlorides
  • Acetaminophen
  • Cobalt
  • Methylcholanthrene
  • Glutathione