Ophthalmologic toxicity after cis-dichlorodiammineplatinum(II) therapy

Cancer Treat Rep. 1978 Oct;62(10):1591-4.

Abstract

Two cases of apparent ophthalmologic toxicity which occurred during treatment with cis-dichlorodiammineplatinum(II) (DDP) are described. In the first case, a patient with testicular carcinoma developed papilledema after three courses of DDP and adriamycin therapy. In the second case, a patient with breast cancer developed retrobulbar neuritis after three courses of DDP therapy. The differential diagnosis and possible explanation for these toxic effects are discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cisplatin / adverse effects*
  • Eye Diseases / chemically induced*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Optic Neuritis / chemically induced
  • Papilledema / chemically induced

Substances

  • Cisplatin