Acerbine has been available for clinical trial since three years ago. Promotion of epithelialization, as well as antiphlogistic, antibacterial and fungicidal actions have been attributed to this preparation. This paper presents a critical appraisal of our own results with Acerbine; initial scepsis was soon dispelled by the evident efficacy of this preparation, both in the form of a lotion and ointment, and its wide scope of application. Moreover, our own studies revealed an excellent effect on keloids, which became smoother and visibly paler. A very good prophylactic and curative effect was observed in respect to all types of skin transplantation. So far Acerbine has been successfully applied in 117 patients who have completed their course of treatment. Acerbine is being currently employed in the case of 16 further patients who are still in hospital. No untoward side effects were recorded. Our findings confirm the opinion of other authors that hospitalization is shortened by the use of this preparation. The availability, more recently, of the new preparation in form of an ointment enables treatment to be continued on an ambulant basis or at home in many cases. Certain new fiies. The results of further explorative investigations into these aspects are under review at present.