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J Virol. 1981 Oct;40(1):314-8.

Varicella-zoster virus vaccine DNA differs from the parental virus DNA.

Abstract

The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus DNA during extensive cell culture passage of the vaccine virus.

PMID:
6270384
PMCID:
PMC256623
[Indexed for MEDLINE]
Free PMC Article

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