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Hypoxia imaging and theranostic potential of [(64)Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms.
Liu T, Karlsen M, Karlberg AM, Redalen KR. Liu T, et al. EJNMMI Res. 2020 Apr 9;10(1):33. doi: 10.1186/s13550-020-00621-5. EJNMMI Res. 2020. PMID: 32274601 Free PMC article. Review.
In addition, emerging studies suggest using [(64)Cu][Cu(ATSM)] for molecular radiotherapy, mainly due to the release of therapeutic Auger electrons from copper-64, making [(64)Cu][Cu(ATSM)] a "theranostic" agent. ...RESULTS: We found that hypoxia selec …
In addition, emerging studies suggest using [(64)Cu][Cu(ATSM)] for molecular radiotherapy, mainly due to the release of therap …
Copper(II) diacetyl-di(N(4)-methylthiosemicarbazone).
The MICAD Research Team. The MICAD Research Team. 2004 Nov 10 [updated 2005 Jul 31]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2004 Nov 10 [updated 2005 Jul 31]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641533 Free Books & Documents. Review.
Cu-ATSM accumulates avidly in hypoxic cells and delineates hypoxic areas within tumors, whereas it washes out in normoxic cells and in tissues where Cu-ATSM is not reduced and retained to the same extent (2-4). ...For this reason, Cu-ATSM …
Cu-ATSM accumulates avidly in hypoxic cells and delineates hypoxic areas within tumors, whereas it washes out in normoxic cell …
Cu-ATSM: a radiopharmaceutical for the PET imaging of hypoxia.
Vāvere AL, Lewis JS. Vāvere AL, et al. Dalton Trans. 2007 Nov 21;(43):4893-902. doi: 10.1039/b705989b. Epub 2007 Sep 25. Dalton Trans. 2007. PMID: 17992274
Copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone), Cu-ATSM, labeled with a positron emitting isotope of copper ((60)Cu, (61)Cu, (62)Cu or (64)Cu) has been shown, in vitro and in vivo, to be selective for hypoxic tissue. In silico studies have explored the …
Copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone), Cu-ATSM, labeled with a positron emitting isotope of copper ((60)Cu, ( …
Alteration of Cellular Reduction Potential Will Change (64)Cu-ATSM Signal With or Without Hypoxia.
Floberg JM, Wang L, Bandara N, Rashmi R, Mpoy C, Garbow JR, Rogers BE, Patti GJ, Schwarz JK. Floberg JM, et al. J Nucl Med. 2020 Mar;61(3):427-432. doi: 10.2967/jnumed.119.230805. Epub 2019 Oct 4. J Nucl Med. 2020. PMID: 31586008 Free PMC article.
We aimed to demonstrate that Cu-ATSM signal is dependent on cellular redox state, irrespective of hypoxia. ...Conclusion:(64)Cu-ATSM signal reflects redox state, and altering redox state impacts (64)Cu-ATSM metabolism. ...
We aimed to demonstrate that Cu-ATSM signal is dependent on cellular redox state, irrespective of hypoxia. ...Conclusion:(64) …
Dosimetry of 60/61/62/64Cu-ATSM: a hypoxia imaging agent for PET.
Laforest R, Dehdashti F, Lewis JS, Schwarz SW. Laforest R, et al. Eur J Nucl Med Mol Imaging. 2005 Jul;32(7):764-70. doi: 10.1007/s00259-004-1756-x. Epub 2005 Mar 23. Eur J Nucl Med Mol Imaging. 2005. PMID: 15785955
PURPOSE: Cu-diacetyl-bis(N4-methylthiosemicarbazone (Cu-ATSM) is an effective marker for the delineation of hypoxic tissue. ...
PURPOSE: Cu-diacetyl-bis(N4-methylthiosemicarbazone (Cu-ATSM) is an effective marker for the delineation of hypoxic tissue. .. …
Application of 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) PET imaging to predict highly malignant tumor grades and hypoxia-inducible factor-1α expression in patients with glioma.
Tateishi K, Tateishi U, Sato M, Yamanaka S, Kanno H, Murata H, Inoue T, Kawahara N. Tateishi K, et al. AJNR Am J Neuroradiol. 2013 Jan;34(1):92-9. doi: 10.3174/ajnr.A3159. Epub 2012 Jun 14. AJNR Am J Neuroradiol. 2013. PMID: 22700754 Free PMC article.
MATERIALS AND METHODS: (62)Cu-ATSM PET was performed in 22 patients with glioma, and the (62)Cu-ATSM SUV(max) and T/B ratio were semiquantitatively evaluated. (62)Cu-ATSM uptake distribution was qualitatively evaluated and compared with M …
MATERIALS AND METHODS: (62)Cu-ATSM PET was performed in 22 patients with glioma, and the (62)Cu-ATSM SUV(max) an …
Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenation.
Lewis JS, Sharp TL, Laforest R, Fujibayashi Y, Welch MJ. Lewis JS, et al. J Nucl Med. 2001 Apr;42(4):655-61. J Nucl Med. 2001. PMID: 11337556 Free article.
We also showed that, in vivo, Cu-ATSM uptake is heterogeneous in animal tumors known to contain hypoxic fractions. ...It also caused the tumor uptake of Cu-ATSM to increase by 35%. Conversely, in animals breathing 100% oxygen, the average tumor pO2 inc …
We also showed that, in vivo, Cu-ATSM uptake is heterogeneous in animal tumors known to contain hypoxic fractions. ...It also …
Heterogeneity in intratumor correlations of 18F-FDG, 18F-FLT, and 61Cu-ATSM PET in canine sinonasal tumors.
Bradshaw TJ, Bowen SR, Jallow N, Forrest LJ, Jeraj R. Bradshaw TJ, et al. J Nucl Med. 2013 Nov;54(11):1931-7. doi: 10.2967/jnumed.113.121921. Epub 2013 Sep 16. J Nucl Med. 2013. PMID: 24042031 Free PMC article.
METHODS: Twenty canine veterinary patients with spontaneously occurring sinonasal tumors (13 carcinomas and 7 sarcomas) were imaged with (18)F-FDG, (18)F-labeled 3'-deoxy-3'-fluorothymidine ((18)F-FLT), and (61)Cu-labeled diacetyl-bis(N(4)-methylthiosemicarbazone) ((61 …
METHODS: Twenty canine veterinary patients with spontaneously occurring sinonasal tumors (13 carcinomas and 7 sarcomas) were imaged with (18 …
Spatially resolved regression analysis of pre-treatment FDG, FLT and Cu-ATSM PET from post-treatment FDG PET: an exploratory study.
Bowen SR, Chappell RJ, Bentzen SM, Deveau MA, Forrest LJ, Jeraj R. Bowen SR, et al. Radiother Oncol. 2012 Oct;105(1):41-8. doi: 10.1016/j.radonc.2012.05.002. Epub 2012 Jun 8. Radiother Oncol. 2012. PMID: 22682748 Free PMC article.
MATERIALS AND METHODS: Ten canine sinonasal cancer patients underwent PET/CT scans of [(18)F]FDG (FDG(pre)), [(18)F]FLT (FLT(pre)), and [(61)Cu]Cu-ATSM (Cu-ATSM(pre)). Following radiotherapy regimens of 50 Gy in 10 fractions, veterinary patients …
MATERIALS AND METHODS: Ten canine sinonasal cancer patients underwent PET/CT scans of [(18)F]FDG (FDG(pre)), [(18)F]FLT (FLT(pre)), and [( …
Comparison of image quality with 62Cu and 64Cu-labeled radiotracers in positron emission tomography whole-body phantom imaging.
Kobayashi M, Mori T, Tsujikawa T, Ogai K, Sugama J, Kiyono Y, Kawai K, Okazawa H. Kobayashi M, et al. Hell J Nucl Med. 2015 May-Aug;18(2):103-7. doi: 10.1967/s002449910203. Epub 2015 Jul 20. Hell J Nucl Med. 2015. PMID: 26187208
OBJECTIVE: PET imaging is possible with copper (Cu) isotopes, (60)Cu, (61)Cu, (62)Cu and (64)Cu. Although (62)Cu- and (64)Cu-labeled radiotracers are often used for preclinical and clinical PET studies, we do not know which radiotracers have better image quality for tumor …
OBJECTIVE: PET imaging is possible with copper (Cu) isotopes, (60)Cu, (61)Cu, (62)Cu and (64)Cu. Although (62)Cu- and (64)Cu-labeled …
22 results