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Neurosci Lett. 1979 Jul;13(2):147-50.

LSD's effect on neuron populations in visual cortex gauged by transient responses of extracellular potassium evoked by optical stimuli.

Abstract

The effects of systemic LSD (10--25 micrograms/kg) on visually evoked [K+]o responses from the striate cortex have been investigated in cats. Elevation of [K+]o was dependent on the orientation, and direction of stimulus movement and showed ocular dominance. LSD most commonly produced a depression of [K+]o transients and a deterioration in their directional selectivity. These observations suggest that the effect of LSD is to produce a net depression in visually evoked neuronal firing.

PMID:
530463
DOI:
10.1016/0304-3940(79)90032-6
[Indexed for MEDLINE]

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