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The following term was not found in PubMed: 5-Bromo-4-methyl-2-thienyl
Page 1
5-Butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(2,4,6-trimethylphenyl)isoxazole.
Harrity JP, Adams H, Davies MW, Wybrow RA, Johnson CN. Harrity JP, et al. Acta Crystallogr C. 2002 Mar;58(Pt 3):o168-9. doi: 10.1107/s0108270101017942. Epub 2002 Feb 20. Acta Crystallogr C. 2002. PMID: 11870316
The X-ray crystal structure analysis of this compound shows two independent molecules in the asymmetric unit, each with approximately coplanar isoxazole and boronate rings....
The X-ray crystal structure analysis of this compound shows two independent molecules in the asymmetric unit, each with approximately coplan …
Ethyl 5-methyl-4-(2,5,5-trimethyl-1, 3-dioxan-2-yl)isoxazole-3-carboxylate.
Zhou P, Fisher JD, Staples RJ, Vij A, Natale NR. Zhou P, et al. Acta Crystallogr C. 2000 Sep;56 ( Pt 9):1146-7. doi: 10.1107/s0108270100008489. Acta Crystallogr C. 2000. PMID: 10986513
The title compound, C(14)H(21)NO(5), possesses an isoxazolyl group in the axial position of the 1,3-dioxanyl ring. ...In this conformation, neither the methyl nor ethoxycarbonyl substituents on the isoxazole are presented towards the dioxanyl chair....
The title compound, C(14)H(21)NO(5), possesses an isoxazolyl group in the axial position of the 1,3-dioxanyl ring. ...In this conform …
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery.
Azzali E, Machado D, Kaushik A, Vacondio F, Flisi S, Cabassi CS, Lamichhane G, Viveiros M, Costantino G, Pieroni M. Azzali E, et al. J Med Chem. 2017 Aug 24;60(16):7108-7122. doi: 10.1021/acs.jmedchem.7b00793. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28749666
Clues from the structure-activity relationships lining up the antitubercular activity were exploited for the rational design of improved analogues. Two compounds, namely N-phenyl-5-(2-(p-tolylamino)thiazol-4-yl)isoxazole-3-carboxamide 7a and N-(pyridin-2-yl)-5 …
Clues from the structure-activity relationships lining up the antitubercular activity were exploited for the rational design of improved ana …
An Isoxazole Strategy for Molybdenum-Mediated Synthesis of 5-Mono- and 4,5-Disubstituted 1H-Pyrrole-2,3-diones.
Galenko EE, Puzyk AM, Novikov MS, Khlebnikov AF. Galenko EE, et al. J Org Chem. 2022 May 6;87(9):6459-6470. doi: 10.1021/acs.joc.2c00386. Epub 2022 Apr 14. J Org Chem. 2022. PMID: 35420424
The synthesis of 5-aryl- and 4-aryl/hetaryl/cyclopropyl/alkynyl-5-aryl-1H-pyrrole-2,3-diones by formal isomerization of isoxazole-5-carbaldehydes mediated Mo(CO)(6) in wet MeCN has been developed. ...
The synthesis of 5-aryl- and 4-aryl/hetaryl/cyclopropyl/alkynyl-5-aryl-1H-pyrrole-2,3-diones by formal isomerization of iso …
Discovery of 5-methyl-N-(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors.
Im D, Moon H, Kim J, Oh Y, Jang M, Hah JM. Im D, et al. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1110-1115. doi: 10.1080/14756366.2020.1758689. J Enzyme Inhib Med Chem. 2020. PMID: 32338093 Free PMC article.
A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigidification of a previous type II FMS inhibitor. Most of quinazoline analogues displayed activity against FLT3 and FLT3-ITD. Compound 7d, …
A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigi …
Design, Synthesis, and Herbicidal Activity of N-Benzyl-5-cyclopropyl-isoxazole-4-carboxamides.
Sun XL, Ji ZM, Wei SP, Ji ZQ. Sun XL, et al. J Agric Food Chem. 2020 Dec 23;68(51):15107-15114. doi: 10.1021/acs.jafc.0c03582. Epub 2020 Dec 10. J Agric Food Chem. 2020. PMID: 33301336
Based on the structures of isoxaflutole (IFT) and N-isobutyl-N-(4-chloro-benzyl)-4-chloro-2-pentenamide, a series of N-benzyl-5-cyclopropyl-isoxazole-4-carboxamides was designed by connecting their pharmacophores (i.e., a multitarget drug design strategy). A total o …
Based on the structures of isoxaflutole (IFT) and N-isobutyl-N-(4-chloro-benzyl)-4-chloro-2-pentenamide, a series of N-benzyl-5-cyclo …
Synthesis and anti-HIV activity of a new isoxazole containing disubstituted 1,2,4-oxadiazoles analogs.
Kumar Kushwaha P, Saurabh Srivastava K, Kumari N, Kumar R, Mitra D, Sharon A. Kumar Kushwaha P, et al. Bioorg Med Chem. 2022 Feb 15;56:116612. doi: 10.1016/j.bmc.2022.116612. Epub 2022 Jan 10. Bioorg Med Chem. 2022. PMID: 35026631
Continuing on our antiviral drug discovery research, we intended to diversify our lead anti-HIV-1 inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles. The resulting molecules isoxazole-1,2,4-oxadiazole analogs were synthesized using mild bases in …
Continuing on our antiviral drug discovery research, we intended to diversify our lead anti-HIV-1 inhibitor by non-classical isosteric repla …
5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of alpha/beta-Mixed Peptides.
Bąchor U, Lizak A, Bąchor R, Mączyński M. Bąchor U, et al. Molecules. 2022 Aug 31;27(17):5612. doi: 10.3390/molecules27175612. Molecules. 2022. PMID: 36080386 Free PMC article.
Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is an important task. Here, we described our investigation of the possibility of 5-amino-3-methyl-isoxazole-4-carboxylic acid (AMIA) application in …
Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is an important task. …
Comparison of two molecular scaffolds, 5-methylisoxazole-3-carboxamide and 5-methylisoxazole-4-carboxamide.
Song Y, Zhang Y, Lee AR, Huang WH, Chen B, Palfey B, Shaw J. Song Y, et al. Curr Pharm Des. 2014;20(1):146-52. doi: 10.2174/13816128113199990584. Curr Pharm Des. 2014. PMID: 23944378 Review.
Leflunomide is a disease-modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Structurally, it is a derivative of 5-methylisoxazole-4-carboxamide. Upon metabolism, the N-O bond in the isoxazole ring is cleaved to form the active metab …
Leflunomide is a disease-modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Structurally, it is a derivati …
C5-Iminosugar modification of casein kinase 1delta lead 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole promotes enhanced inhibitor affinity and selectivity.
von Drathen T, Ure EM, Kirschner S, Roth A, Meier L, Woolhouse AD, Cameron SA, Knippschild U, Peifer C, Luxenburger A. von Drathen T, et al. Arch Pharm (Weinheim). 2022 May;355(5):e2100497. doi: 10.1002/ardp.202100497. Epub 2022 Feb 17. Arch Pharm (Weinheim). 2022. PMID: 35174898
To achieve selectivity for our casein kinase (CK) 1 inhibitor series, we elected to endow our previous CK1delta-hit, 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole (1), with chiral iminosugar scaffolds. These scaffolds were attached to C5 of the isoxazo …
To achieve selectivity for our casein kinase (CK) 1 inhibitor series, we elected to endow our previous CK1delta-hit, 3-(4-fluorophenyl)-5 …
11,104 results
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