Spinal epidural and synovial lipomatosis in a 3-year-old Eurasian dog receiving sustained steroid therapy

Vet Med Sci. 2022 Jul;8(4):1373-1377. doi: 10.1002/vms3.842. Epub 2022 Jun 22.

Abstract

This report describes a spinal cord epidural and synovial lipomatosis in a 3-year-old neutered male Eurasian dog. This dog presented for ambulatory paraparesis and was previously treated with immunosuppressive dosages of prednisolone for 2 years. Computed tomography (CT) myelography and magnetic resonnance imaging (MRI) images identified dorsal compression of the thoraco-lumbar spinal cord by hypertrophic epidural fat. Histological examination identified extensive well-differentiated mature adipose tissue in the subepithelial area of the tarsal synovium. Prednisolone is a reported predisposing factor in humans with lipomatosis.

Keywords: dog; epidural lipomatosis; fatty infiltration; synovial lipomatosis.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Dog Diseases* / diagnostic imaging
  • Dog Diseases* / drug therapy
  • Dog Diseases* / pathology
  • Dogs
  • Epidural Space / pathology
  • Humans
  • Lipomatosis* / diagnostic imaging
  • Lipomatosis* / veterinary
  • Male
  • Myelography / veterinary
  • Prednisolone / therapeutic use
  • Steroids

Substances

  • Steroids
  • Prednisolone