Pulmonary lymphoproliferative disorders in children: a practical review

Pediatr Radiol. 2022 Jun;52(7):1224-1233. doi: 10.1007/s00247-022-05335-5. Epub 2022 Mar 29.

Abstract

Pulmonary lymphoproliferative disorders represent an uncommon spectrum of proliferation of lymphoid tissue in the lung parenchyma ranging from benign hyperplasia to malignancy. They tend to occur in certain clinical situations and have typical imaging features that together can be used by the radiologist to suggest these entities as part of the differential diagnosis. We review key clinical, histopathological and computed tomography features of pulmonary lymphoproliferative disorders in children including follicular bronchiolitis, lymphoid interstitial pneumonia, granulomatous-lymphocytic interstitial lung disease, lymphoma and post-transplant lymphoproliferative disorder to familiarize the pediatric radiologist with this group of disorders.

Keywords: Children; Computed tomography; Lungs; Lymphoproliferative disorders; Pulmonary.

Publication types

  • Review

MeSH terms

  • Child
  • Diagnosis, Differential
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases, Interstitial* / diagnostic imaging
  • Lung Diseases, Interstitial* / pathology
  • Lymphoproliferative Disorders* / diagnostic imaging
  • Lymphoproliferative Disorders* / pathology
  • Tomography, X-Ray Computed / methods