Intraoral localized methotrexate-associated lymphoproliferative disorders concurrent with antiresorptive agent-related osteonecrosis of the jaw: A case report and literature review

Masaki Minabe; Taiki Suzuki; Masumi Komatsu; Kazuhiko Hashimoto; Takeshi Nomura

doi:10.1002/ccr3.3192

Intraoral localized methotrexate-associated lymphoproliferative disorders concurrent with antiresorptive agent-related osteonecrosis of the jaw: A case report and literature review

Clin Case Rep. 2020 Sep 13;8(12):2926-2935. doi: 10.1002/ccr3.3192. eCollection 2020 Dec.

Authors

Masaki Minabe¹, Taiki Suzuki^{1

2}, Masumi Komatsu¹, Kazuhiko Hashimoto³, Takeshi Nomura¹

Affiliations

¹ Department of Oral Medicine, Oral and Maxillofacial Surgery Tokyo Dental College Ichikawa Japan.
² Division of Oral and Maxillofacial Surgery SUBARU Health Insurance Society Ota Memorial Hospital Ota Japan.
³ Department of Pathology and Laboratory Medicine Tokyo Dental College Ichikawa General Hospital Ichikawa Japan.

Abstract

Intraoral localized methotrexate-associated lymphoproliferative disorders can cause antiresorptive agent-related osteonecrosis of the jaw associated with infection due to its immunological abnormalities and ulcer formation.

Keywords: antiresorptive agent‐related osteonecrosis of the jaw; denosumab; methotrexate‐associated lymphoproliferative disorders; rheumatism; rheumatoid arthritis.

Publication types

Case Reports