Management of methotrexate-induced neurotoxicity with aminophylline plus dextromethorphan in a pediatric patient with pineoblastoma

Pediatr Blood Cancer. 2020 Dec;67(12):e28515. doi: 10.1002/pbc.28515. Epub 2020 Jul 25.

Authors

Mara Faye Rubin¹, Alexis K Kuhn²

Affiliations

¹ Department of Pharmacy, Nationwide Children's Hospital, Columbus, Ohio.
² Department of Pharmacy, Mayo Clinic, Rochester, Minnesota.

PMID: 32710710
DOI: 10.1002/pbc.28515

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adolescent
Aminophylline / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Brain Neoplasms / drug therapy*
Brain Neoplasms / pathology
Bronchodilator Agents / therapeutic use
Cisplatin / administration & dosage
Cyclophosphamide / administration & dosage
Dextromethorphan / therapeutic use*
Disease Management
Drug Therapy, Combination
Etoposide / administration & dosage
Excitatory Amino Acid Antagonists / therapeutic use
Female
Humans
Methotrexate / administration & dosage
Neurotoxicity Syndromes / drug therapy*
Neurotoxicity Syndromes / etiology
Neurotoxicity Syndromes / pathology
Pineal Gland / drug effects*
Pineal Gland / pathology
Pinealoma / drug therapy*
Pinealoma / pathology
Prognosis

Substances

Bronchodilator Agents
Excitatory Amino Acid Antagonists
Aminophylline
Etoposide
Dextromethorphan
Cyclophosphamide
Cisplatin
Methotrexate