Magnetic resonance imaging in Pelizaeus-Merzbacher disease

Pediatr Neurol. 1988 Mar-Apr;4(2):124-5. doi: 10.1016/0887-8994(88)90055-0.

Abstract

Cranial computed tomography of a boy with clinical characteristics of the classic form of Pelizaeus-Merzbacher disease did not reveal a notable abnormality other than enlarged ventricles. Magnetic resonance imaging, however, demonstrated diffuse changes in the white matter with sparing of scattered small areas, suggesting persistent myelin islands which are a typical neuropathologic finding in Pelizaeus-Merzbacher disease. Magnetic resonance imaging appears more useful than computed tomography in confirming the diagnosis of Pelizaeus-Merzbacher disease.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Brain / pathology*
  • Cerebellum / pathology
  • Cerebral Cortex / pathology
  • Cerebral Ventricles / pathology
  • Diffuse Cerebral Sclerosis of Schilder / diagnosis*
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Myelin Sheath / pathology*