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Curr Biol. 2020 Feb 5. pii: S0960-9822(20)30098-1. doi: 10.1016/j.cub.2020.01.054. [Epub ahead of print]

Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis.

Author information

1
Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA.
2
Facultad de Ciencias Químicas, Dpto. Química Biológica Ranwel Caputto-CIQUIBIC, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria de Córdoba, Córdoba X5000HUA, Argentina.
3
Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA; Department of Cell Biology, University of Oklahoma Health Science Center, 865 Research Parkway, Oklahoma City, OK 73104, USA. Electronic address: pezzar@omrf.org.

Abstract

Telomere-led rapid chromosome movements or rapid prophase movements direct fundamental meiotic processes required for successful haploidization of the genome. Critical components of the machinery that generates rapid prophase movements are unknown, and the mechanism underlying rapid prophase movements remains poorly understood. We identified S. cerevisiae Mps2 as the outer nuclear membrane protein that connects the LINC complex with the cytoskeleton. We also demonstrate that the motor Myo2 works together with Mps2 to couple the telomeres to the actin cytoskeleton. Further, we show that Csm4 interacts with Mps2 and is required for perinuclear localization of Myo2, implicating Csm4 as a regulator of the Mps2-Myo2 interaction. We propose a model in which the newly identified functions of Mps2 and Myo2 cooperate with Csm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cytoskeleton.

KEYWORDS:

LINC complex; S. cerevisiae; live imaging; meiosis; nuclear envelope; telomere-led rapid chromosome movements; yeast

PMID:
32059771
DOI:
10.1016/j.cub.2020.01.054

Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

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