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Biochem Biophys Res Commun. 2020 Feb 4. pii: S0006-291X(20)30224-2. doi: 10.1016/j.bbrc.2020.01.141. [Epub ahead of print]

Optogenetics for neural transplant manipulation and functional analysis.

Author information

1
Technische Universität Dresden, CRTD - Center for Regenerative Therapies at TU Dresden, D-01307, Dresden, Germany.
2
Technische Universität Dresden, CRTD - Center for Regenerative Therapies at TU Dresden, D-01307, Dresden, Germany; Universitäts-Augenklinik Bonn, University of Bonn, Dep. of Ophthalmology, D-53127, Bonn, Germany. Electronic address: Volker.busskamp@tu-dresden.de.

Abstract

Transplantation of neural stem cells (NSCs) or NSC-derived neurons into the brain is a promising therapeutic approach to restore neuronal function. Rapid progress in the NSCs research field, particularly due to the exploitation of induced pluripotent stem cells (iPSCs), offers great potential and an unlimited source of stem cell-derived neural grafts. Studying the functional integration of these grafts into host brain tissues and their effects on each other have been boosted by the implementation of optogenetic technologies. Optogenetics provides high spatiotemporal functional manipulations of grafted or host neurons in parallel. This review aims to highlight the impact of optogenetics in neural stem cell transplantations.

KEYWORDS:

Channelrhodopsins; Neural stem cell therapy; Neurological disorders; Optogenetics; Transplant

PMID:
32033753
DOI:
10.1016/j.bbrc.2020.01.141
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