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Genes Dev. 2020 Feb 1;34(3-4):147-148. doi: 10.1101/gad.336164.119.

Better safe than sorry-preventing mitotic segregation of meiotic chromosomes.

Author information

1
Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.

Abstract

The distinctive segregation patterns of chromosomes in mitosis and meiosis are dictated in part by the kinetochores, the structures on chromosomes that attach them to the microtubules of the spindle. Inappropriate mitosis-like chromosome segregation in meiosis leads to gametes with incorrect chromosome numbers. New findings by Chen and colleagues (pp. 209-225) in this issue of Genes & Development reveal how cells restructure their kinetochores when they enter meiosis. Their results describe an interconnected set of mechanisms that provides multiple layers of protection from the carryover of mitotic chromosome segregation patterns into meiotic cells.

KEYWORDS:

APC; Aurora B; Ndc80; chromosome; kinetochore; meiosis; proteolysis

PMID:
32015052
PMCID:
PMC7000914
[Available on 2020-08-01]
DOI:
10.1101/gad.336164.119

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