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Rev Med Inst Mex Seguro Soc. 2020 Jan 30;57(3):181-186.

First report of infectious endocarditis due to Histoplasma capsulatum in Mexico

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda”, Unidad de Investigación Médica en Epidemiología Clínica. Ciudad de México, México

Abstract

in English, Spanish

Background:

Infectious endocarditis of fungal origin is rare but of high mortality. The agents involved are mainly opportunists of the genus Candida and Aspergillus; however other fungi can also cause this disease.

Clinical case:

The case of a woman who suffered unknown origin intermittent fever for several months; and in who, by blood culture (after lysis-centrifugation) and molecular biology techniques, Histoplasma capsulatum was identified as etiological agent. The histological study showed abundant intracellular yeasts and hyphae in intracardiac vegetations.

Conclusion:

This first report of infectious endocarditis by H. capsulatum in Mexico highlights the importance of using in addition to manual blood culture (lysis-centrifugation) and histological study, faster and more sensitive diagnostic methods, such as serology and molecular biology, to confirm or rule out an invasive fungal infection and identify the agents.

KEYWORDS:

Endocarditis; Histoplasma capsulatum; Diagnosis; Mexico

PMID:
31995345

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