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Nat Hum Behav. 2020 Mar;4(3):308-316. doi: 10.1038/s41562-019-0805-1. Epub 2020 Jan 20.

GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits.

Author information

1
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
2
Department of Genetics, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
3
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
4
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
5
Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Japan.
6
Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
7
Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
8
Department of Psychiatry, Fujita Health University School of Medicine, Toyotake, Japan.
9
Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
10
Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
11
Division of Molecular Pathology, the Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan.
12
RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
13
Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. yoichiro.kamatani@riken.jp.
14
Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. yoichiro.kamatani@riken.jp.
15
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.
16
Laboratory of Statistical Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.
17
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.

Abstract

Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and drinks per week), beverages (coffee, green tea and milk) and foods (yoghurt, cheese, natto, tofu, fish, small whole fish, vegetables and meat) in Japanese individuals (n = 58,610-165,084) collected by BioBank Japan, the nationwide hospital-based genome cohort. Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits (P < 3.8 × 10-9). Of these, ten associations between five loci and eight traits were new findings. Furthermore, a phenome-wide association study revealed that five of the dietary trait-associated loci have pleiotropic effects on multiple human complex diseases and clinical measurements. Our findings provide new insight into the genetics of habitual consumption.

PMID:
31959922
DOI:
10.1038/s41562-019-0805-1

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