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Trends Parasitol. 2020 Feb;36(2):158-169. doi: 10.1016/j.pt.2019.12.003. Epub 2019 Dec 14.

Organoids for Liver Stage Malaria Research.

Author information

1
The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Victoria, Australia.
2
The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Victoria, Australia. Electronic address: boddey@wehi.edu.au.

Abstract

Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans. 2D culture models provide extremely beneficial tools to investigate Plasmodium biology but they have limitations. More complex 3D structural networks, such as organoids, have unveiled new avenues for developing more physiological tissue models, and their application to malaria research offers great promise. Here, we review current models for studying Plasmodium infection with a key focus on the obligate pre-erythrocytic stage that culminates in blood infection, causing malaria, and discuss how organoids should fulfil an important and unmet need.

KEYWORDS:

Plasmodium; drug; hepatocyte; hypnozoite; sporozoite; vaccine

PMID:
31848118
DOI:
10.1016/j.pt.2019.12.003

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