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J Pept Sci. 2019 Dec 17:e3239. doi: 10.1002/psc.3239. [Epub ahead of print]

Celogentin mimetics as inhibitors of tubulin polymerization.

Author information

1
School of Chemistry, The University of Melbourne, Victoria, 3010, Australia.
2
Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia.
3
Melbourne Dental School and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia.

Abstract

Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether bonds. Several of the simplified bicyclic peptides displayed potent inhibition of tubulin polymerization.

PMID:
31847053
DOI:
10.1002/psc.3239

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