Send to

Choose Destination
Science. 2019 Dec 6;366(6470):1251-1255. doi: 10.1126/science.aaz0898.

Functional diversity of human intrinsically photosensitive retinal ganglion cells.

Author information

Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Drive (S3140), Salt Lake City, UT 84132, USA.
Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.


Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a subset of cells that participate in image-forming and non-image-forming visual responses. Although both functional and morphological subtypes of ipRGCs have been described in rodents, parallel functional subtypes have not been identified in primate or human retinas. In this study, we used a human organ donor preparation method to measure human ipRGCs' photoresponses. We discovered three functional ipRGC subtypes with distinct sensitivities and responses to light. The response of one ipRGC subtype appeared to depend on exogenous chromophore supply, and this response is conserved in both human and mouse retinas. Rods and cones also provided input to ipRGCs; however, each subtype integrated outer retina light signals in a distinct fashion.


Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center