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Trends Immunol. 2019 Dec;40(12):1105-1119. doi: 10.1016/j.it.2019.10.001. Epub 2019 Nov 27.

Impact of Historic Migrations and Evolutionary Processes on Human Immunity.

Author information

1
Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500HB Nijmegen, The Netherlands. Electronic address: Jorge.DominguezAndres@radboudumc.nl.
2
Department of Internal Medicine and Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, 6500HB Nijmegen, The Netherlands; Department for Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania.

Abstract

The evolution of mankind has constantly been influenced by the pathogens encountered. The various populations of modern humans that ventured out of Africa adapted to different environments and faced a large variety of infectious agents, resulting in local adaptations of the immune system for these populations. The functional variation of immune genes as a result of evolution is relevant in the responses against infection, as well as in the emergence of autoimmune and inflammatory diseases observed in modern populations. Understanding how host-pathogen interactions have influenced the human immune system from an evolutionary perspective might contribute to unveiling the causes behind different immune-mediated disorders and promote the development of new strategies to detect and control such diseases.

KEYWORDS:

autoimmune diseases; evolution; immunity; migrations; pathogens; selective pressure

PMID:
31786023
DOI:
10.1016/j.it.2019.10.001

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