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Curr Cardiol Rev. 2019 Nov 28. doi: 10.2174/1573403X15666191129100928. [Epub ahead of print]

The Association Between Keratoconus and Mitral Valve Prolapse: A Systematic Review.

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Department of Internal Medicine, Banner University Medical Center - South Campus, 2800 E Ajo Way, Tucson, AZ 85713, United States.
Department of Ophthalmology, Jamaica Hospital Medical Center, 8900 Van Wyck Expy, Richmond Hill, NY, United States.



The debate pertaining to the association between keratoconus (KC) and mitral valve prolapse (MVP) continues to occur among physicians. The results of cross-sectional studies attempting to present the coexisting prevalence of these two diseases remains indeterminate. We compiled the first meta-analysis to determine the pattern of prevalence between the two diseases.


Two separate literature searches for cross-sectional studies were performed for this meta-analysis. The first search encompassed finding literature comparing the prevalence of KC between patients with MVP and a control group. The second search pertained to finding studies comparing the prevalence of MVP patients with KC and a control group.


Six studies reported the prevalence of MVP in patients with KC and a control group. The prevalence was 41.6% in patients with KC and 11.5% in patients without KC (OR = 7.06 [95% CI = 2.41-20.64]). There was significant heterogeneity among the studies (I2=84%). Two studies showed the prevalence of KC in patients with MVP and a control group. The prevalence was 17.0% in patients with KC and 2.9% in the control group (OR = 5.07 [95% CI = 1.08-23.83]). There was no heterogeneity within the analysis (I2=0%) Conclusion: There is statistically significant co-existing prevalence of MVP and KC. Patients with KC are more likely to present with MVP, and patients with MVP are more likely to present with KC.


Association; Cardiology; Epidemiology; Keratoconus; Mitral Valve Prolapse; Ophthalmology

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