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Curr Cardiol Rev. 2019 Nov 28. doi: 10.2174/1573403X15666191129100928. [Epub ahead of print]

The Association Between Keratoconus and Mitral Valve Prolapse: A Systematic Review.

Author information

1
Department of Internal Medicine, Banner University Medical Center - South Campus, 2800 E Ajo Way, Tucson, AZ 85713, United States.
2
Department of Ophthalmology, Jamaica Hospital Medical Center, 8900 Van Wyck Expy, Richmond Hill, NY, United States.

Abstract

OBJECTIVE:

The debate pertaining to the association between keratoconus (KC) and mitral valve prolapse (MVP) continues to occur among physicians. The results of cross-sectional studies attempting to present the coexisting prevalence of these two diseases remains indeterminate. We compiled the first meta-analysis to determine the pattern of prevalence between the two diseases.

METHODS:

Two separate literature searches for cross-sectional studies were performed for this meta-analysis. The first search encompassed finding literature comparing the prevalence of KC between patients with MVP and a control group. The second search pertained to finding studies comparing the prevalence of MVP patients with KC and a control group.

RESULTS:

Six studies reported the prevalence of MVP in patients with KC and a control group. The prevalence was 41.6% in patients with KC and 11.5% in patients without KC (OR = 7.06 [95% CI = 2.41-20.64]). There was significant heterogeneity among the studies (I2=84%). Two studies showed the prevalence of KC in patients with MVP and a control group. The prevalence was 17.0% in patients with KC and 2.9% in the control group (OR = 5.07 [95% CI = 1.08-23.83]). There was no heterogeneity within the analysis (I2=0%) Conclusion: There is statistically significant co-existing prevalence of MVP and KC. Patients with KC are more likely to present with MVP, and patients with MVP are more likely to present with KC.

KEYWORDS:

Association; Cardiology; Epidemiology; Keratoconus; Mitral Valve Prolapse; Ophthalmology

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